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KMID : 0370219810250040187
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Yakhak Hoeji
1981 Volume.25 No. 4 p.187 ~ p.192
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Studies on the Coprecipitates of Two Ingredients with PVP
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백우현/Paik WH
김정우/송영준/Kim JW/Song YJ
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Abstract
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In order to increase the dissolution rate on the mixture of sulfamethoxazole and trimethoprim (SMX-TMP), their coprecipitates with polyvinylpyrrolidone (PVP) were studied. Coprecipitates prepared with various ratios of SMX and TMP were examined such as hygroscopicity, apparent solubility, apparent partition coefficient and the dissolution behavior of SMX-TMP’’s coprecipitates and their physical mixtures. The hygroscopicity of coprecipitates were less than that of physical mixtures. The apparent solubility and dissolution rate of SMX-TMP’’s coprecipitates were found to be greatly increased. The dissolution rates of SMX and TMP in the coprecipitates were decreased when the ratio of two ingredients to PVP was smaller, and the dissolution rate of SMX was increased when the ratio of SMX to TMP was larger.
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